Abstract
Inflammatory myofibroblastic tumour (IMT) is a neoplasm of intermediate biological potential with a predilection for lung and soft tissue of children and young adults. Histologically, the tumour is composed of myofibroblastic cells intermixed with a lymphoplasmacytic inflammatory infiltrate. Re-arrangements of the anaplastic lymphoma kinase (ALK) gene are present in approximately 50% of IMTs. Alternative kinase fusions have recently been described and include fusions in the ROS1, ETV6, RET and platelet derived growth factor receptor beta (PDGFRB) gene.
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