Abstract
A set of equations was worked out to estimate the rapidity of the outward penetration of glucose from the hepatic intracellular compartment into the plasma compartment. In dynamic steady states at different blood sugar levels the average rate constant was found to be 0.46 min−1. Thus the rate at which glucose leaves the liver cell is rapid, but not instantaneous. The flux rates of glucose across the liver cell membrane were calculated and were found to be approximately eight times higher than the rate of glucose production. Two non-metabolizable glucose analogues, L-glucose and 3-O-methylglucose, were found to be distributed in 85% of the total water content of the liver.
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