Abstract
Introduction: This study was aimed to assess Cardiac marker like C-RP, lipid profile, CK-MB, AND SGOT in diabetic and non diabetic patients with myocardial infarction. Methods: This study was conducted in Department of Biochemistry during period of 2006-2007 in SSG hospital, Vadodara, Gujarat. Biochemical investigation including Fating blood sugar (FBS), Post prandial blood sugar (PP2BS), CK-MB, SGOT, LDH, Total cholesterol, Triglyceride, HDL-C, LDL-C were determined using semi auto analyzer and fully auto analyzer (Erba cam50 & Mura logo tech respectively) with ready to used kits. Results: In this study, levels of CK-MB (p<0.001) and SGOT (p=0.0057), C-RP (p=0.01), Triglyceride (p=0.005) are significantly increased in patients of myocardial with diabetes mellitus, while HDL level decreased in patients of myocardial infarction with diabetes mellitus compared to non diabetic MI patients. Statistical Analysis: Data was compiled in excel sheet, analyzed for percentage and proportion. Statistical analyses were carried out by using one way ANOVA, value of p<0.1 has been considered statistically significant. Conclusion: Study suggest that cardiac markers like C-RP, lipid profile, CK-MB, AND SGOT levels were significantly increased in patients suffering from myocardial infarction with diabetes mellitus compared to patients of myocardial infarction without diabetes mellitus.
Highlights
This study was aimed to assess Cardiac marker like C-RP, lipid profile, Creatine kinase-MB (CK-MB), AND Serum glutamate oxaloacetate transaminase (SGOT) in diabetic and non diabetic patients with myocardial infarction
The latter seems to be more likely in diabetic patients, because autonomic neuropathy is a common feature of diabetes, and abnormalities of the autonomic nerve fibers were demonstrated histological in diabetic patients who died after painless myocardial infarction
There are a few researchers who have reported higher C-RP15 level in myocardial infarction patients with diabetes mellitus compared to patients of myocardial infarction without diabetes mellitus
Summary
This study was aimed to assess Cardiac marker like C-RP, lipid profile, CK-MB, AND SGOT in diabetic and non diabetic patients with myocardial infarction. Conclusion: Study suggest that cardiac markers like C-RP, lipid profile, CK-MB, AND SGOT levels were significantly increased in patients suffering from myocardial infarction with diabetes mellitus compared to patients of myocardial infarction without diabetes mellitus. There could be several explanations for the different pattern of symptoms in patients with diabetes mellitus, including different thresholds of pain sensitivity, psychological denial, or the presence of autonomic neuropathy leading to sensory denervation The latter seems to be more likely in diabetic patients, because autonomic neuropathy is a common feature of diabetes, and abnormalities of the autonomic nerve fibers were demonstrated histological in diabetic patients who died after painless myocardial infarction. Of the presence or absent of other risk factors diabetes mellitus add to the risk for cardiovascular morbidity and mortality[10] because of this diabetes mellitus should be defined as a “state of premature cardiovascular death associated with chronic hyperglycemia”
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