THE ESTIMATE OF ADIPOKINES, CYTOKINES, MARKERS OF ENDOTHELIAL DYSFUNCTION AND HEMOSTASIS CORRELATION WITH THE STATE OF TARGET ORGANS IN YOUNG PATIENTS WITH HYPERTENSION COMBINED WITH ABDOMINAL OBESITY

Abstract

Background. To estimate the correlation of adipokines, cytokines, endothelial dysfunction markers and hemostasis with state of target organs in young patients with hypertension and abdominal obesity. Materials and methods. The blood content of adipokines, cytokines, endothelial dysfunction markers and hemostasis in patients with hypertension, abdominal obesity and their combination was determined. Standard 12-lead ECG, two-dimensional echocardiography and duplex scanning of the brachiocephalic arteries were performed in all patients. Results. In young patients with combination of hypertension and abdominal obesity were determined the increased levels of leptin, interleukin-6, monocyte chemoattractant protein type 1, endothelin, angiotensin II and prothrombotic changes in hemostasis. Among this patients were revealed hypertrophy of the left ventricle myocardium and increased intima-media complex thickness compared to those in groups with isolated hypertension, isolated abdominal obesity and the control group. The greatest diagnostic significance for predicting myocardial hypertrophy of the left ventricle according to the ROC-analysis were endothelin level >3,49 pg/ml and interleukin-6 level >5,67 pg/ml.