The epidemiological study on human metapneumovirus、human bocavirus and human adenovirus infections among children with acute respiratory tract infections in Guangzhou, from 2016-2018

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Objective To investigate the epidemic and clinical features on human metapneumovims (hMPV) and human bocavirus (HBOV) among pediatric patients with acute respiratory infections (ARTIs) in Guangzhou. Methods A total of 13597 children with ARTIs from January 2016 to August 2018 were recruited. The pharyngeal swab specimens were collected. The ADV/hMPV and HBoV were detected by using real-time PCR. Results In 13597 children, 1062 children (7.81%) were ADV positive on swab specimens, 576 children (4.24%) were HBoV positive, 312 children (2.29%) were HMPV positive. The detection rates of ADV in 2016、2017 and 2018 year were 6.73%、6.24% and 10.93%, respectively. The detection rates of HBOV in 2016、2017 and 2018 were 4.43%、4.21% and 4.06%, respectively. The detection rates of HMPV in 2016、2017 and 2018 were 0.91%、2.47% and 3.53%, respectively, HMPV was not detected at five months of 2016 year. The epidemiological peaks of ADV and HBOV were mainly occurred in summer and autumn. The epidemiological peaks of HMPV were mainly occurred in spring and early summer. The highest detection rates of virus were in children with Non-severe community acquired pneumonia. The detection rates of children infection with HMPV and HBOV cause asthmatic bronchitis was higher than that infection with ADV. In our study, the infection rate of ADV、HMPV and HBOV were 63.84%、76.28% and 86.98% in patients ≤2 years old. Conclusion In Guangzhou, our study suggested that ADV and HBOV had been important agents causing ARTIs in pediatric patients. HMPV infection rates were relatively low. HMPV and HBOV are the most important pathogens in infants and toddlers with wheezing. Key words: Respiratory tract infection; Human adenovirus; Human bocavirus; Human metapneumovirus; Epidemiology