Abstract
Letters and Corrections15 May 1990The Eosinophilia-Myalgia SyndromeAndrew Freese, Stephen F. Finn, Matthew J. DuringAndrew FreeseSearch for more papers by this author, Stephen F. FinnSearch for more papers by this author, Matthew J. DuringSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-112-10-795 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the Editor:Since the initial description of the eosinophilia-myalgia syndrome and recognition of its link to tryptophan ingestion, we have received several inquiries regarding our previous letter on the potential neurotoxicity of tryptophan (1). Our concern focused on the metabolic relation between tryptophan and the known neurotoxin, quinolinic acid, which acts as an agonist of theN-methyl-D-aspartate excitatory amino acid receptor. Since then, we have shown a dramatic responsiveness of brain extracellular fluid levels of quinolinic acid to tryptophan loading in rats (2). A single intraperitoneal dose of tryptophan (100 mg/kg body weight) elevated striatal brain extracellular fluid quinolinic...
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