Abstract
The immunological enhancement of virus infectivity was observed only when avian antisera to the test viruses (rabbitpox virus and Murray Valley encephalitis virus) were assayed in a cell system of avian origin. The enhancing activity was found to reside in the IgG fraction of the antiserum. The enhancement phenomenon is of a transient nature, and a prolonged interaction between the virus and antibody results in the neutralization of infectivity. Studies of the dose response relationship for neutralization indicate that the combination of a single antibody molecule with the virus may be sufficient to neutralize the infectivity of the virus. The enhancing activity of chicken antisera could not be accounted for by the greater net negative charge carried by chicken IgG than the IgG of mammalian species. Enhancement could not be accounted for by the presence in chicken antisera of an antibody molecule that had an affinity for chicken embryo fibroblasts.
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