Abstract
The neutralizing activity of rabbit 7 S γ-globulin antibody directed against rabbitpox virus can be increased by chemical treatments that decrease the negative charge carried by the molecule, and can be decreased by treatments (chemical or enzymatic) that increase the negative charge carried by the antibody molecule. The decreased activity of modified antibody is not the result of a failure of the antibody to combine with its antigen. The neutralizing activity of any given antibody preparation is not wholly determined by the physicochemical nature of the antibody. The cell system used to assay neutralizing activity plays a very important part in the process of neutralization, and the same antibody preparation may show different activities when assayed in chicken embryo fibroblasts under different physiological conditions.
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