The Endogenous Apolipoprotein A-I Enhances The Uptake Of Oxidated Low Density Lipoprotein By Macrophages

Abstract

Background and Aims: Apolipoprotein A-I (ApoA-I) is the main structural and functional protein component of high-density lipoprotein. Recently we found the moderate expression of endogenous apoA-I in human monocytes and macrophages and showed the anti-inflammatory influence of endogenous ApoA-I on macrophages. The homogeneous population of monocytes divides to the ApoA-I-rich and ApoA-I-poor macrophages during the differentiation. The functions of macrophagal ApoA-I in the development of atherosclerotic lesions are still unknown. Here we show the participation of macrophagal ApoA-I in the uptake of oxidated Low Density Lipoprotein (oxLDL) and study the apoA-I gene regulation in macrophages by oxLDL.