The Enantioselective High‐Pressure Diels—Alder Reaction of 1‐Methoxybuta‐1,3‐diene with tert‐Butyldimethylsilyloxyacetaldehyde Catalyzed by (Salen)Co(II) and (Salen)Cr(III)Cl Complexes.

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Abstract The high-pressure (10–11 kbar) reaction of 1-methoxybuta-1,3-diene ( 1 ) with tert -butyldimethylsilyloxyacetaldehyde ( 2 ), catalyzed by the chiral (salen)Co(II) 4 or (salen)Cr(III)Cl 5 complexes, has been studied. We found that the reaction afforded, in good yield (up to 90%) and both with very good diastereoselectivity (up to 92%) and enantioselectivity (up to 94% ee), the [4 + 2]cycloadducts 3 , which are compounds of significant synthetic interest.