Abstract

Consisting of gamma delta heterodimers, γδT cells are inflammatory cells that play a pivotal role in a number of autoimmune neurological diseases. This review considers the emerging role of γδT cells in neurological diseases having epilepsy components such as Rasmussen’s encephalitis (RE), and cortical dysplasia (CD), along with other neurological conditions such as high grade gliomas, infection-induced encephalitis, multiple sclerosis (MS) and ischemic stroke. All these neurological diseases have γδT cell involvement which suggests that therapies directed toward gamma delta T cells with immunotherapeutics may have an important role in the treatment of these conditions including seizures and stopping disease progression, and that following these cells could be used as biomarkers of certain neurological diseases.

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