Abstract
Quantitative MRI acquisitions, such as diffusion MRI, have been used extensively in neuropsychiatric research. Diffusion MRI provides valuable metrics related to composition, microstructure, and architecture of brain tissue. These metrics are defined on an absolute scale and should be measurable with high accuracy on different scanners. Unfortunately, a common finding in several multicenter studies is that diffusion measurements are not highly reproducible across scanners and centers. In this talk we will review the most important factors that contribute to the current situation and discuss possible strategies for improvement.
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