Abstract
In the presence of atropine and guanethidine, the electrically evoked contractile response of the rabbit iris sphincter muscle is mediated by tachykinins. Two highly selective NK 1 receptor antagonists, (±) CP-96,345 and spantide II, concentration dependently inhibited the contraction with pIC 50 values of 5.4 and 6.1, respectively. A highly selective NK 2 receptor antagonist, actinomycin D, was inactive, while another NK 2 receptor antagonist of moderate selectivity, MEN 10,376, produced a slight inhibition of the contration at high concentrations. Our results suggest that the electrically evoked, tachykinin-mediated contractile response of the rabbit iris sphincter muscle involves NK 1 receptors only.
Published Version
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