Abstract
Rat retinae were loaded with radioactive GABA in vitro and the efflux of this compound then studied. The loss of radioactivity occurred in three stages with widely different rate constants. Efflux was considerably reduced when GABA metabolism was inhibited by amino-oxyacetic acid. Significantly more GABA, and less of its metabolites, were released by dark-adapted retinae as compared with those in the light. No modification of the release process was observed, however, during subsequent illumination of these retinae. Raising the K + concentration of the perfusing medium to 60 mM caused a pronounced rise in GABA output lasting 15–20 min. A similar response was evoked by electrical field stimulation of the retinae, and neither process was altered by the omission of Ca 2+ from the incubating medium.
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