The efficiency of local therapy of kneeosteoarthritis

Abstract

Purpose: to assess the efficacy of Ketoprofen local therapy in patients with knee osteoarthritis (OA), and its effect on the intensity of pain and quality of life. Methods: we have observed 23 subjects aged 50-69 years old with knee joint OA I-II grade. The diagnosis knee OA was based on X-ray method and interpreted by Kellgren-Lawrence classification. All participants were divided into two groups: group І - 13 patients with Ketoprofen application on the knee joint twice a day during 10 days, and II group - 10 patients with vaseline (petroleum jelly) application on the knee joint twice a day during 10 days. The study was based on three visits dynamic assessment: screening, the tenth days of local therapy and the last - on the twentieth day after finishing of therapy. The results of the treatment were evaluated by the WOMAC scale, Leken index and the15-meter test. Results: in group I and II there were no significant difference between age, anthropometric data and pain intensity. In the group I, there were detected a significant decrease on the intensity of pain, stiffness and improved the daily activity according to the WOMAC subscales and a decreased the duration of the 15-meter test: When comparing the effectiveness of treatment in the two groups after 10 and 30 days, there were detected the significantly reduction of the intensity of pain, stiffness and limitation of daily activity in group I. Thus, on the 10th day of treatment in patients using the ketoprofen application, the intensity of pain decreased by 41.7% compared with the group II, where the intensity of pain decreased by only 5.3% and in patients of the group I the positive dynamics was maintained by 30th day of the study. Compared with the screening data, the intensity of pain in the group I decreased by 17% In the group I on the 10th day the level of stiffness decreased by 35.2% (p = 0.1), but on the 30th day it increased by 13.9%. In the group II there was no significant dynamics on the 10th and 30th day of the study. The dynamics of daily activity among patients using the ketoprofen was also higher. On the 10th day of treatment, patients of group I noted an improvement in daily activity by 34% (p <0.001), and on the 30th day by 11.8% compared with the results before treatment. The duration of 15-meter test was significantly decreased by 12.9% (p=0.02). We have detected no significant differences in the group II. Also we have detected no adverse reactions among patients used the ketoprofen treatment during the whole observation period Conclusions: local therapy of ketoprofen have significantly decreased the intensity of pain and improved the quality of life of patients with knee OA that confirm it effect.