Abstract
Objective To explore the efficacy and safety of sodium ozagrel combined with edaravone in the treatment of acute cerebral infarction.Methods 207 patinets were randomly assigned to receive sodium ozagrel combined with edaravone(69 patients,combination group),sodium ozagrel alone (69 patients,ozagrel group),or edaravone alone(69 patients,edaravone group). The coagulation indice and Neuropathy Disability Score(NDS)were assessed before and 14 days after treatment in the three groups;and the efficacy and safety were compared.Results After a 14day therapy,the efficacy in the combination group was obviously superior to that in ozagrel group or in edaravone group(P＜0.05).Platelet levels and coagulation indice were within the normal range.Conclusions Sodium ozagrel combined with edaravone has a synergistic effect in the treatment of acute cerebral infarction.The combination therapy has no obvious adverse reactions and is worth popularizing. Key words: Acute cerebral infarction; Sodium ozagrel; Edaravone
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