The efficacy of different doses of fentanyl combined with propofol for artificial abortion

Abstract

Objective To explore the anesthetic effects of different doses of fentanyl combined with propofol for artificial abortion. Methods 178 women in first trimeter who requested artificial abortion were randomly assigned to receive single intravenous injection of fentanyl of 2 μg.kg-1 and propofol of 1.5mg.kg-1 (89 women, control group) or fentanyl of 1 μg. kg-1 and propofol of 1.5 mg.kg-1 (89 women, study group). The onset time of anaesthesia, time to regaining consciousness, respiratory depression, and adverse reactions were noted. Results The onset time of anaesthesia was shorter in the study group than in the control group [(1.2 ± 0.5)min vs. (1.3 ± 0.5)min]; time to regaining consciousness was longer in the control group than in the study group[(7.8 ± 1.8) min vs.(6.4 ± 1.6)min]; The rate of decrease in SPO2and RR was obviously higher in the control group than in the study. No serious adverse reactions occurred intraoperatively and postoperatively in both groups. Conclusions Fentanyl of lμg.kg-1 combined with propofol of 1.5mg.kg-1, a better anaesthetic method for artificial abortion, can enhance the effects of analgesia and anaesthesia, significantly reduce the amount of propofol use, resulting in shorter period of anesthetic induction and consciousness recovery, but does not enhance the effects of propofol on inhibition of respiration and circulation. Key words: Artificial abortion; Fentanyl; Different doses; Propofol