The efficacy of combination chemotherapy with oxaliplatin for advanced colorectal cancer

Abstract

Objective To observe the efficacy and toxicity of oxaliplatin (L-OHP) combined with 5-fluorouracil (5-FU) and leucovorin (LV) for advanced colorectal cancer, and to compare the clinical value of 2 week- or 3 week-regimen. Methods According to the chronology, 95 patients with advanced colorectal cancer were randomly divided into: ① treatment group 1 (47 cases): L-OHP 85 mg/m2, intravenous drip 2h for day 1; LV, intravenous drip 2 h for days 1 and 2; 5-fluorouracil (5-Fu) 400 mg/m2 were injected after LV,followed by 5-Fu 600 mg/m2, continuous intravenous drip 22 h, d1 、d2, repeated every 2w, at least 6 cycles. ②treatment group 2 (48 cases): L-OHP 130 mg/m2, intravenous drip 2 h, d1; LV 200 mg/m2, intravenous drip 2h,followed by 5-Fu 500 rag/d, intravenous drip 4 h for days 1 to 5, repeated every 3 weeks, at least 4 cycles. The two groups were injected Tropisetron 100 mg 30 min or Azasetron 10 mg for oral administration in order to prevent vomiting before, chemotherapy.Results The efficacy was similar in the two groups, the total efficacy achieved 46.8% and 41.6% (P>0.05); The incidence of adverse reactions were similar in the two groups. The main adverse reactions were gastrointestinal reactions, myclosuppression, neurological toxicity, and alopecia (P>0.05); CEA and CA-199 were significantly decreased after treatment (P 0.05). The median survival and median progression-free survival were significantly different (P<0.01). Conclusions L-OHP combined with LV and 5-FU is a relatively effective, less toxic regimen in the treatment of advanced colorectal cancer, and it is suggested to choose the standard 2 week-regime first. Key words: Oxaliplatin; 5-Fluorouracil ; Leucovorin; Advanced colorectal cancer; Combinationchemotherapy