Abstract
Objective To investigate the therapeutic effect and tolerability of capecitabine combined with oxaliplatin on advanced colorectal cancer. Methods Twenty patients with advanced colorectal cancer were treated with oxaliplatin 130mg/m2 intravenously once per week and capecitabine 1000mg/m2 orally twice daily for 14 days. Every 3 weeks was a treatment cycle. The effect was evaluated after two treatment cycles. Result Among 20 patients treated with oxaliplatin and capecitabine, complete response was 1 case and partial response was 7 eases. The total effective rate was 40.0%. Adverse effects were mainly grade Ⅰ～Ⅱ that includes marrow inhibitory, nausea and vomiting, diarrhea, mouth ulcer, peripheral neuritis and hand-foot syndrome. There was no serious chemo-therapy-related adverse effect. Conclusion The combined chemotherapy with oxaliplatin and capecitabine is an effective and better tolerance in treatment of advanced colorectal cancer and well worth clinical application. Key words: Advanced colorectal cancer; Capecitabine; Oxaliplatin; Combination chemotherapy
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