The efficacy of 36 cases of dysfunctional uterine bleeding treatment by levonorgestrel

Abstract

Objective To study the clinical efficacy of levonorgestrel (brand name:Yu Ting) in treatment for dysfunctional uterine bleeding (DUB).Methods 56 cases diagnosed as peri-menopausal patients with anovulatory DUB by gynecology outpatient department in our hospital from January 2009 to January 2011 were treated with oral administration of norethisterone,but no good effect was found in 36 cases, then changed to take levonorgestrel for 3 menstrual cycles.The bleeding time,1 month after treatment,3 months follow-up observation of menstrual flow,menstrual cycle changes were observed,and the levels of Hb,ALT,AST,BUN and CRE before and after treatment were also monitored.Results The rapid hemostatic rate of Yu Ting orally taking for 6 hours was 69.44％,hemostatic rate during 24 ～ 48 hours was 30.56％.The effective rate 1 month after treatment was 91.66％,the one of 3 months was 72.22％,there was a significant difference among them (P＜ 0.05); 3 months before and after treatment,the levels of Hb,ALT,AST,BUN and CRE were compared,Hb level significantly increased after treatment,with a significant difference (P＜ 0.05); there was no significant changes in levels of ALT,AST,BUN and CRE (P ＞ 0.05).Conclusion Levonorgestrel has good effects in treatment for dysfunctional uterine bleeding,obvious results in hemostasis,a low incidence rate of side effects during treatment,but longterm effects need further observation. Key words: Dysfunctional uterine bleeding; Levonorgestrel