The efficacy evaluation of sequential mechanical ventilation in the treatment of chronic obstructive pulmonary disease combined with respiratory failure

Abstract

Objective To study the clinical efficacy of sequential mechanical ventilation in the treatment of chronic obstructive pulmonary disease combined with respiratory failure.Methods 60 cases of chronic obstructive pulmonary disease combined with respiratory failure in our hospital from Feb 2012 to Dec 2013 were randomly divided into control group (invasive mechanical ventilation treatment) and observation group (invasive and noninvasive sequential mechanical ventilation treatment),30 cases in each group.The cardiopulmonary function (HR,RR,FEV1％,FEV1/FVC),blood gas indexes (PaO2,PaCO2,SaO2) before and after treatment,and the incidence of re-intubation and VAP in two groups were compared.Results Compared to pre-treatment,the cardiopulmonary function and blood gas indexes significantly improved on post-treatment in both two groups,with statistically significant differences (P ＜ 0.05).Compared to control group,the cardiopulmonary function and blood gas indexes on post-treatment in observation group significantly improved,and the incidences of re-intubation and VAP were obviously lower,with statistically significant differences (P ＜ 0.05).Conclusions Invasive and noninvasive sequential mechanical ventilation has a significant efficacy in the treatment of chronic obstructive pulmonary disease combined with respiratory failure,which can obviously improve patients' cardiopulmonary function and blood gas indexes,reduce the incidence of re-intubation and VAP,worthy of clinical promotion. Key words: Sequential mechanical ventilation; Chronic obstructive pulmonary disease; Respiratory failure; Efficacy