Abstract
McTAGGART, J., AND WILLS, E. D., The Effects of Whole- and Partial-Body Irradiation on Circulating Anterior Pituitary Hormones and Testosterone and the Relationship of These Hormones to Drug-Metabolizing Enzymes in the Liver. Radiat. Res. 72, 122-133 (1977). Doses within the range of 850 to 1500 rad given to the whole body, head, or lowertrunk region of male rats cause a marked depression in the rate of oxidative demethylation of drugs in the liver endoplasmic reticulum, 3 to 4 days after the irradiation. The Vmax of the enzyme system is depressed and the Km increased. Irradiation to the whole body, head, or lower trunk also causes a fall in the circulating levels of testosterone and luteinizing hormone (LH) and the concentrations of these hormones are markedly reduced 3 to 4 days after the irradiation. Injections of testosterone or anterior pituitary extract effectively restore the activity of the liver enzyme system after irradiation of the head or lower trunk. It is concluded that whole-body irradiation causes inhibition of drug-metabolizing enzymes in the liver by a complex series of interrelated effects on the
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
