Abstract
Doxorubicin (DOX) is a powerful chemotherapeutic agent, but its use is associated with adverse side effects including skeletal muscle dysfunction. Exercise prior to DOX treatment has been shown to attenuate muscle dysfunction, but the effects of exercise on DOX myotoxicity during and following treatment remain unknown. Purpose: The purpose of this study was therefore to explore the effects of endurance exercise during and following DOX treatment on skeletal muscle function. Methods: Male rats received DOX or saline weekly for 6 weeks and were housed in either voluntary running wheel cages or sedentary condition. Grip force was measured at baseline, week 5, and week 10, and ex vivo skeletal muscle function was assessed at week 10. Results: Wheel running during and following DOX treatment attenuated late-onset grip force reduction and promoted improved function in type I, or slow muscle. Conclusion: Skeletal muscle function can be preserved during and following DOX treatment with low-volume endurance exercise, but this protection may be limited to type I muscle.
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