The effects of transfer day in intracytoplasmic sperm injection (ICSI) pregnancies on first trimester screening test results

Abstract

Objects: To compare first trimesterscrening (FTS) serum markers free β-human chorionic gonodotropin (free β-hCG and pregnancy associated plasma protein A (PAPP-A) of blastocyst versus cleavage stage embryo transfers after assisted reproductive technologies (ART).Methods: Retrospective examinations of 123 women who conceived with ART were subjected to FTS from January 2017 to December 2017 at Bahçeşehir University Göztepe Medical Park Hospital In Vitro Fertilization (IVF) Unit.The age,gestational week,ultrasound (US) markers and biochemistry markers(PAPP-A,free β-hCG) were collected.Outcomes were regarded as meaningful when the p < 0.05. Statistical Package For Social Sciences (SPSS) v.17.0 for Windows was preferred to make statistical analysis.Results: PAPP-A amounts were remarkably low in day-3 (cleavage stage embryos) transfer intracytoplasmic sperm injection (ICSI) pregnancies compared to day-5 (blastocyst stage embryos) transfer ICSI pregnancies.Free β-hCG amounts weren’t significantly different in two groups (p=0.371). NT was unaffected by the transferenceday (p=0.21). Also CRL wasunaffected by the transferenceday (p=0.693). No differences appeared between 3rd and 5th day embryo transference according to maternal age (p=0.616), weight (p=0.693) and gestational age (p=0.742) at sampling. Conclusion: Today, the datas about the effects of ART over the ingredients of combined FTS for chromosomal analysis are contentious yet.Day-3 ICSI pregnancies had meaningfully low PAPP-A amounts which support the requirement to properly set the combined FTS risks algoritm. These outcomes are likely to be because of changings in the placenta of ART pregnancies.