Abstract
Tobacco smoke is one of the causes of oxidative stress that is leading to attenuation of the antioxidative body protective barrier by means of decreasing the levels of intra- and extracellular antioxidants. The effect of tobacco smoke on plasma levels of two main forms of Vitamin E, α- and γ-tocopherol, in passive smokers (urinary cotinine concentration 50–500 μg/L) and active smokers (urinary cotinine concentration >500 μg/L) were studied. Slight, but statistically significant decreases in plasma α-tocopherol level in passive and active smokers in comparison with non-smokers (by 5.7% and 9.2%, respectively) were found. The plasma γ-tocopherol levels remained unchanged. The Pearson’s correlation coefficient for the plasma α-tocopherol level and the urinary cotinine concentration in passive and active smokers was −0.431, P=0.004 and −0.534, P<0.001, respectively, and for γ-tocopherol in similar conditions −0.190, P=0.217 and 0.346, P=0.027, respectively. The obtained results indicate the secondary role that α- and γ-tocopherol play in the process of tobacco smoke free radical scavenge, or they may also reflect the body increased anti-oxidative mobilization in response to oxidative stress evoked by tobacco smoke.
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