Abstract
Materials and Methods: We analyzed cognitive performance data collected in a prospective intergroup trial (Proc ASCO 17:1545, 1998) which randomized 203 eligible/analyzable adult patients with supratentorial low-grade gliomas to low-dose (50.4 Gy/28 fractions) versus high-dose (64.8 Gy/36 fractions) localized radiation therapy. Median follow-up is 7.4 years in the 101 patients still alive. Folstein mini-mental status exam (MMSE) scores and neurologic function scores (NFS) recorded at baseline and at each study evaluation were analyzed to assess cognitive and physical function over time. A loss or gain of greater than 3 points in MMSE was considered clinically significant.
Published Version
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