The Effects of Protein Kinase Inhibitor Mzeta on Retention and Reconsolidation of Long-Term Memory in Conditioned Food Aversion in Snails

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1.25 mg/kg) given without a reminder two days after training were ineffective, while ZIP (2.5 mg/kg) evoked transient memory impairment one day after injection with spontaneous recovery on day 10. Injections of ZIP (5 mg/kg) without a reminder led to memory impairment and the development of stable amnesia. On repeat training of animals 11 days after induction of amnesia induced by ZIP (5 mg/kg), the number of combined food and reinforcement stimuli required to form the memory was similar to that in initial training. ZIP (5 and 10 mg/kg) combined with a reminder induced amnesia, though repeat training at 11 days led to dose-dependent increases in the rate of formation of memory than on initial training. It is suggested that in snails trained to conditioned food aversion, inhibition of a PKMzeta-like enzyme without a reminder induced “fading of the memory trace,” while repeat training formed a new memory. PKMzeta is evidently not directly involved in the process of memory reconsolidation, though reminding prevented the amnestic effect of ZIP.