Abstract
Publisher Summary General anesthetics exert their action on the central nervous system. The dependence of cerebral function on its blood supply makes an understanding of the influence of general anesthetics on cerebral blood flow (CBF) necessary. Barbiturate anesthesia depresses cerebral metabolism in proportion to the depth of anesthesia. The cerebral blood flow follows these changes in metabolic rate, so that the greatest reduction in CBF occurs along with the deepest anesthesia. Data on the effect of neuroleptanalgesia on the cerebral circulation is sparse. Kreuscher, who found a reduction of CBF and cerebral metabolism after the simultaneous intravenous injection of droperidol (0.28 mg/kg) and fentanyl (0.007 mg/kg) in the dog have performed a thorough investigation. Freeman and Ingvar showed that fentanyl increased cortical blood flow in the unanesthetized cat depending on the dosage (0.005-0.02 mg/kg). As a contribution to this problem, the effect of fluonisone and fentanyl (10 mg and 0.2 mg/kg resp.) on the central circulation by repetitive CBF measurements is studied. Also concerning the effect of halothane on CBF, conflicting reports have been published. This chapter performs CBF studies under standardized conditions with two purposes in mind, firstly to determine the effect of halothane on cerebral haemodynamics and secondly to study the effect of a combination of nitrous oxide and halothane on cerebral blood flow.
Published Version
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