Abstract
Pesticides used to increase agricultural production have hazard effects for human being health. The present study reports the serum levels of total sialic acid (TSA) in the pesticide applicators in the agriculture areas of the Kahramanmaras, Turkiye. This study included a total of 79 volunteer individuals. Pesticide group included 47 men who were working as pesticide applicators. Control group comprised healthy males (n=32), nonsmokers and nondrinkers and also nonexposured to pesticide and other chemicals chronically. Serum TSA level was measured with the Warren method modified by Pönniö et al. The TSA concentrations were significantly higher in the pesticide groups (p < 0.001) than those of control subjects. We can conclude from the results obtained that serum TSA was affected by pesticide exposure. This finding may be an indication of harmful effects of pesticides. Increased serum TSA levels in pesticide exposure might be related to various diseases e.g. various cancers, which are also often associated with elevated serum TSA levels. However further studies are necessary to evaluate the concentrations of serum TSA in pesticide exposure.
Highlights
The use of pesticides has increased dramatically in both developed and developing countries during the last few decades
Pesticide group included 47 men who were working as pesticide applicators, in the cotton growing areas of the Kahramanmaras, a city and agriculture area in southern Turkiye, and lived in same area
Serum total sialic acid (TSA) level was measured in pesticide group and compared with healthy control subjects who nonexposure to pesticide and nonsmokers and nondrinkers
Summary
The use of pesticides has increased dramatically in both developed and developing countries during the last few decades. Pesticides used to increase agricultural production have hazard effects for human being health [6]. Pesticides with an extremely high acute toxicity may be metabolized and eliminated from the body; following long-term low exposure, they may be less toxic and without carcinogenic or mutagenic properties. Pesticides with low acute toxicity can accumulate in the body and chronic toxicity after long-term exposure even in comparatively low doses [6]. It has been observed that pesticides have hazard effects for human being health. Such effects may vary from an influence on the reproductive system and immunosuppressive effects, to the promotion of carcinogenic activity [6,18,19]. Elevated concentrations of serum TSA were suggested as a potent cardiovascular risk factor in the general population [13,14]
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