The effects of peritoneal dialysis and hemodialysis on serum tumor necrosis factor-alpha, interleukin-6, interleukin-10 and C-reactive-protein levels.

Ali Borazan,Ahmet Yilmaz,Selim Aydemir,Taner Bayraktaroglu,Hasan Ustün,Mehmet Sert,Yucel Ustundag

doi:10.1080/09511920410001713493

Ali Borazan, Ahmet Yilmaz + Show 5 more

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https://doi.org/10.1080/09511920410001713493

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Abstract

BACKGROUND: Markers of an acute phase reaction, such as C-reactive protein (CRP) or tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-6, are predictive for cardiovascular morbidity and mortality in normal subjects and in chronic renal failure patients. In this study, we aimed to investigate serum TNF-alpha, IL-6, IL-10 and CRP levels in continuous ambulatory peritoneal dialysis (CAPD) and hemodialysis (HD) patients. MATERIALS AND METHODS: Serum levels of TNF-alpha, IL-6, IL-10 and CRP levels were measured in 30 patients who were just diagnosed with end-stage renal failure and treated, with 16 CAPD (nine female, seven male) and 14 HD (eight female, six male) patients, before CAPD or HD treatment and after 3 months from the beginning of CAPD or HD in patients with no clinical signs of infection. The control groups were 20 healthy persons of similar age and sex. Serum levels of TNF-alpha, IL-6, IL-10 and CRP were measured by enzyme-linked immunosorbent assay in stable CAPD and HD patients and in healthy persons. RESULTS: The mean serum levels of TNF-alpha, IL-6, IL-10 and CRP showed no significant differences between the CAPD and HD patients for the beginning values and the third month of treatment. However, serum TNF-alpha, IL-6, IL-10 and CRP levels were higher than the control group in the CAPD and HD patients regarding the beginning values and the third month of treatment (p < 0.001). CONCLUSIONS: CAPD and HD of the renal replacement therapy have no effects on serum CRP and cytokines.

Highlights

Cardiovascular diseases are the major reason for mortality and morbidity of patients with chronic renal failure (CRF).[1]
The continuous ambulatory peritoneal dialysis (CAPD) group consisted of 16 patients with a mean age of 41.69/6.0 years, whereas the HD group consisted of 14 patients with a mean age of 43.09/8.0 years, and the healthy group consisted of 20 patients (11 female, nine male) with a mean age of 42.09/9.0
In CAPD and HD patients the serum tumor necrosis factor-alpha (TNF-a), IL-6, IL-10 and C-reactive protein (CRP) levels were higher than levels in the control group both at baseline and 3 months after treatment (p B/0.001)

Summary

Introduction

Cardiovascular diseases are the major reason for mortality and morbidity of patients with chronic renal failure (CRF).[1]. The inflammatory response is orchestrated by cytokines, especially tumor necrosis factor-alpha (TNF-a) and interleukin (IL)-6 Both regulate the production of acute-phase proteins, have potent effects on lipid and carbohydrate metabolism, and are linked with an increased risk of coronary artery disease in subjects with normal renal function.[3,4] Proinflammatory cytokines regulate vascular adhesion. Markers of an acute phase reaction, such as C-reactive protein (CRP) or tumor necrosis factor-alpha (TNF-a) and interleukin (IL)-6, are predictive for cardiovascular morbidity and mortality in normal subjects and in chronic renal failure patients. Serum TNF-a, IL-6, IL-10 and CRP levels were higher than the control group in the CAPD and HD patients regarding the beginning values and the third month of treatment (p B/0.001). Conclusions : CAPD and HD of the renal replacement therapy have no effects on serum CRP and cytokines

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Conclusion