Abstract
In this study, we aimed to investigate plasma homocysteine (Hcy) and serum C-reactive protein (CRP) levels in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients, and the relation among them. This study was carriedout on 52 HD patients, 26 CAPD patients and a control group of 22 healthy persons. Blood samples were taken from the patients for Hcy and CRP measurements. Serum CRP level was found to be high in 48.1% of HD patients, 69.2% of CAPD patients and 4.5% of the healthy control group. Plasma Hcy level was found out to be above the normal limits in 73.1% of HD patients, 65.4% of CAPD patients and 9% of the healthy control group. There was a significant positive relation (r = 0.384, p < 0.001) between the levels of plasma Hcy and serum CRP in HD and CAPD patients. The high levels of Hcy and CRP were found out to be higher in HD and CAPD patients than in the control group. In order to determine the risk rate of Hcy and CRP for coronary artery disease, extensive investigations are required in patients with chronic renal failure that also have coronary artery disease.
Highlights
Patients and methodCardiovascular diseases are the major reason for mortality and morbidity of patients with chronic renal failure.[1]
We aimed to examine the serum levels of plasma Hcy and serum C-reactive protein (CRP) and the relationship between CRP, Hcy, and measures of therapy adequacy (Kt/V, serum albumin) in patients with chronic renal failure, in HD patients and in treated continuous ambulatory peritoneal dialysis (CAPD) patients
The deaths associated with the end-stage renal disease occur as a result of the fatal cardiovascular diseases rather than the direct sequels of uremia, with the exception of poorly developed countries where the deaths associated with this condition occur as a result of the direct sequels of uremia
Summary
Patients and methodCardiovascular diseases are the major reason for mortality and morbidity of patients with chronic renal failure.[1]. We aimed to examine the serum levels of plasma Hcy and serum CRP and the relationship between CRP, Hcy, and measures of therapy adequacy (Kt/V, serum albumin) in patients with chronic renal failure, in HD patients and in treated continuous ambulatory peritoneal dialysis (CAPD) patients. This study was carried on 52 patients (19 female, 33 male) undergoing HD due to the end stage of renal failure, 26 patients (nine female, 17 male) undergoing CAPD and 22 healthy persons (eight female, 14 male) as a control group in our center after gaining their written approval It is noteworthy that the risk factors defined for coronary artery disease such as heredity, hypertension, diabetes, smoking, and a high level of blood lipids had been shown even at the earliest stages of renal failure.[2,3] In recent times the finding of high serum C-reactive protein (CRP), which is the marker of both hyperhomocysteinemia and inflammation, is considered a high risk factor for atherosclerotic vascular diseases in patients with chronic renal diseases, but some studies found no association or only a small association between plasma homocysteine (Hcy) levels and cardiovascular disease.[2,4,5]
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