Abstract
Time-of-flight (TOF) positron emission tomography (PET) can improve signal-to-noise ratio (SNR) relative to conventional PET by improving coincidence localization and reducing random coincidences. Previous work showed that good TOF resolution can dramatically improve SNR in the absence of attenuation. This paper examines the effect of attenuation, scatter and randoms coincidences on SNR in TOF. The SimSET program was modified to generate random events and used to simulate multiple realizations of cylindrical phantoms, adding attenuation, scatter and randoms one-by-one. Improving TOF resolution generally improved SNR, but the improvement over conventional tomography was not well predicted by a widely used model.
Published Version
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