Abstract
The Netrin-1 is a molecule of the 63KD-expressible laminin-dependent molecule secreted by neurons in the midline of the ventricular tube of the vertebrate neuronal tube and is involved in the growth and differentiation of the nervous system as well as angiogenesis as an axonal conduction molecule. The topical use of these adhesives over the past three decades has had a significant effect on reducing the volume of bleeding and accelerating tissue repair and reducing the risk of invasive surgeries and their complications, even in the treatment of hemophilia, it is necessary to use blood and coagulation products This product reduces patient complications and costs. These components are harvested from the stored plasma on the day of operation, and after mixing in the operating position, they coagulate after approximately 10 seconds and cause adhesion, prevent bleeding and neural tissue repair.
Highlights
The Netrin-1 is a molecule of the 63KD-expressible laminin-dependent molecule secreted by neurons in the midline of the ventricular tube of the vertebrate neuronal tube and is involved in the growth and differentiation of the nervous system as well as angiogenesis as an axonal conduction molecule [1]
The Netrin-1 is a member of the family of homologous molecules: Deleted in Colorectal Cancer (DCC) and Uncoordinated-5 homolog (UNC5H) include UNC5H2, UNC5H1, UNC5H3 and UNC5H4
Netrin-1 and fibrinogen can be prepared from a human plasma doner [30]
Summary
The Netrin-1 is a molecule of the 63KD-expressible laminin-dependent molecule secreted by neurons in the midline of the ventricular tube of the vertebrate neuronal tube and is involved in the growth and differentiation of the nervous system as well as angiogenesis as an axonal conduction molecule [1]. In the growth of the fetal spinal cord, the niter-1, with its effect on the receptors in neurons axons, directs them to the lateral lateral margin of the spinal cord [3]. Deleted in Colorectal Cancer (DCC) receptors and Uncoordinated-5 homolog (UNC5H), are connected to the Netrin-1 and involved in axonal guidance. They play a role in regulating the angiogenesis and homeostasis of various tissues. Deleted in Colorectal Cancer (DCC) and Unc-5 homolog receptors in the absence of the Netrin-1, initiate pro-apoptotic signals, acting similar to tumor suppressors. Pro-apoptotic signals generated by Deleted in Colorectal Cancer (DCC) receptors and (UNC5H) Unc-5 homolog are protective mechanisms for tumor growth and metastasis [5]
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