Abstract
Nerous system diseases, both central and peripheral, bring an incredible burden onto patients and enormously reduce their quality of life. Currently, there are still no effective treatments to repair nerve lesions that do not have side effects. Stem cell–based therapies, especially those using dental stem cells, bring new hope to neural diseases. Dental stem cells, derived from the neural crest, have many characteristics that are similar to neural cells, indicating that they can be an ideal source of cells for neural regeneration and repair. This review summarizes the neural traits of all the dental cell types, including DPSCs, PDLCs, DFCs, APSCs and their potential applications in nervous system diseases. We have summed up the advantages of dental stem cells in neural repair, such as their neurotrophic and neuroprotective traits, easy harvest and low rejective reaction rate, among others. Taken together, dental stem cells are an ideal cell source for neural tissue regeneration and repair.
Highlights
Nervous system injuries, both central and peripheral, can lead to severe negative outcomes, including hypoesthesia and paralysis
The dental pulp stem cells (DPSCs) secretome is highly enriched in neurotrophic factors, amyloid beta‐degrading enzymes (NEPs) and anti‐apoptotic factors, demonstrating that DPSCs are an ideal candidate for therapy of Alzheimer's disease (AD).[74]
This review summarizes the traits of the various types of den‐ tal stem cells and their capacities for use in neural repair treat‐ ments
Summary
Both central and peripheral, can lead to severe negative outcomes, including hypoesthesia and paralysis.
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