Abstract
This work was carried out to determine the effect of aqueous extract of moringa olieferia on liver enzymes of mercury induced hepatotoxicity in adult wistar rats. Twenty four adult wistar rats weighing between 190-270g were allocated into four groups of six animals each. Group A served as the control and received 0.5ml of distilled water, group B received 0.5ml of moringa extract, group C received 0.35ml of mercury while group D received 0.35ml of mercury and 0.5ml of moringa extract. The oral administration lasted for twenty eight days between the hours of 12-3pm. Twenty four hours after the last administration; the animals were weighed and recorded. The levels of mean aspartate aminotransferase (AST), Alanin aminotransferase (ALT) and alkaline phosphotase (ALP) in group C was significantly higher (p<0.001) than the control and groups B and D. The result from this study shows that no adverse biochemical changes are associated with the use of moringa extract even when administered with mercury. The result also shows the hepatoprotectivity of moringa olieferia on mercury induced hepatocytes.
Highlights
Plants are a major source of novel anti-oxidant and hepatoprotective agents since many industrial drugs are derived as a result of knowledge got from folklore medicine[1]
ALT, AST, alkaline phosphotase (ALP) activities were used to measure the protective effect of M.oleifera on mercury induced hepatotoxicity in wistar rats was examined and interpreted and the result is presented in table 1 below; there was significant (p
There was a similar trend of observed for serum ALP levels compared with AST levels
Summary
Plants are a major source of novel anti-oxidant and hepatoprotective agents since many industrial drugs are derived as a result of knowledge got from folklore medicine[1]. Some of the herbal preparations speed up the natural healing processes of the liver[12]. Moringa oleifera is the most widely cultivated species of a monogeric family, the Moringacea e that is native to the sub-Himalayan tracts of India, Pakistan, Bangladesh and Afghanistan. Moringa oleifera or the horseradish tree is a pan-tropical species that is known. It is believed to have variety usages which include combating malnutrition, anticancer and is being promoted as a panacea 3,4,5,6,11. M. oleifera extracts or silymarin (as a reference) appears to enhance the recovery from hepatic damage induced by antitubercular drugs
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