Abstract
The present study describes the effects of dopants of Mn and/or Ni on the structural, magnetic and in vivo/in vitro performances of β-tricalcium phosphate (β-TCP) bioceramics synthesized by a sol-gel method. Both types of dopants caused significant effects on the structure-related parameters of β-TCP, including the crystallite dimensions and lattice parameters. The magnetic properties of as-prepared samples were found to be affected by the type and amount of the dopant(s). The in vitro antimicrobial activities of doped β-TCPs against American Type Culture Collection (ATCC) reference bacterial and fungal strains were evaluated. Among them, only 1.35Ni-TCP displayed an effective antimicrobial activity against Gram-positive bacteria (50 μg/mL Minimum Inhibitory Concentration (MIC) range), while other types of doped β-TCPs did not possess with such effect. The in vivo tests showed that each formulation could be a good nominate for bone healing and bone treatment.
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