Abstract
The effect of increasing strut porosity on the osteoinductive ability of silicate substituted calcium phosphate (SiCaP) biomaterials was investigated in an ectopic ovine model. Implants with strut porosities of 22.5%, 32.0% and 46.0% were inserted into the parapsinalis muscle. At 8, 12 and 24weeks histological sections were prepared. Sections were examined using backscattered scanning electron microscopy and un-decalcified histology. Bone area, implant area and bone-implant contact were quantified. At 8weeks there was no significant difference between the groups in terms of bone area and implant area. However at 12weeks, the amount of bone formation observed was significantly greater in SiCaP-46 (6.17±1.51%) when compared with SiCaP-22.5 (1.33±0.84%) p=0.035. Results also showed significantly increased amounts of bone-implant contact to the SiCaP-46 scaffold (3.30±1.17%) compared with SiCaP-22.5 (0.67±0.52%, p=0.043) at 8weeks and 12weeks; (SiCaP-46 (21.82±5.59%) vs SiCaP-22.5 (3.06±1.89%), p=0.012). At 24weeks, bone formation and graft resorption had significantly increased in all groups so that the level of bone formation in the SiCaP-46 group had increased 75-fold to 30.05±8.38%. Bone formation was observed in pores <10μm. Results suggest that bone graft substitute materials with greater strut porosity are more osteoinductive.
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