Abstract
1. 1. Neurulae and post-hatched Xenopus embryos were exposed to LSD at a concentration of 0.06 μg. per ml. for 6 hours. 2. 2. Monoamine oxidase (MAO) and 5-hydroxytryptophan decarboxylase (5-HTPD) activities in whole embryos were changed. 3. 3. Hydroxyindole- O-methyltransferase (HIOMT) was unchanged in whole embryos. 4. 4. MAO and 5-HTPD were unaltered in brain. 5. 5. HIOMT was altered in brains of embryos exposed to LSD at post-hatching. The level was almost zero. It was not lowered in brains of neurulae exposed to LSD. 6. 6. It is suggested that the result is a secondary effect of altered 5-HT ontogeny.
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