The Effects of Kiwi Fruit and Star Anise on the Liver and Lipid Profiles Changes in Mice Carcinoma Induced with Ehrlich Ascites

Abstract

The objective of this study was to estimate chemical constituents, total phenolic, total flavonoids were determined in kiwi and star anise. In addition, biological experimental, in mice, injected with Ehrlich ascites carcinoma (EAC) and treated by cisplatin, kiwi juice, star anise, and their combination and compared with the mice normal group. As well as determination of mRNA gene expression in EAC Cells was quantitative by Real-Time PCR (RT-qPCR) analysis and histological experimental in the liver. The results showed that the nutrition values of kiwi fruit were higher than star anise. The results indica that the lipids profiles were improved in groups taken a collection of kiwi and star anise, followed by kiwi juice and star anise. Moreover, the results showed that when the EAC mice group was co-treated with kiwi juice, star anise, and their collection, the CAT and GPx were increased and TBARS were improved. In addition, RNA was extracted from the liver using a total RNA isolation kit and mRNA gene expression in EAC Cells was quantitative Real-Time PCR (RTqPCR) and the Histological experimental were confirmed these results. Conclusion: the kiwi and star anise as a natural source of new anticancer compounds with antiproliferative, and it would be worthy isolation and identification of new anticancer medicine.