Abstract
Abstract Neither insulin in small or large doses, nor metrazol or electric shock treatments, have any specific effect on the level of blood pyruvate, and probably none on the lactate level, in human beings. The concentration of these substances bore no relation to the blood sugar level nor to the condition of brain functions. Blood pyruvate and lactate rose and fell together, and the rises seemed to be the result only of muscular activity. In metrazol and electric shock the rises of both substances, and of blood glucose, were very high; curare decreased the effect of metrazol convulsions on blood lactate, pyruvate, and glucose. The changes in blood pyruvate were less marked than those of lactate.
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