Abstract
Investigating the effects of idazoxan and efaroxan imidazoline receptor antagonists on cognitive functions with the rat Y-maze test; an internationally recognized experimental pattern of behavior, is to be used in order to evaluate the effects of test substances on the simple spatial memory of the laboratory animals. Our experimental evaluation tested the influence induced by idazoxan and efaroxan on the short-term memory on rats. In the experiment were used eighteen (18) male Wistar rats which were randomly divided into three groups (I - Control, II - IDZ and III - EFR) comprising of 6 animals each, treated intraperitoneally according to the following protocol: group I (Control): distilled water 0.5 mL/100 g body weight; group II (IDZ): idazoxan 3 mg/kg body weight; group III (EFR): efaroxan 1 mg/kg body weight. The purpose of this research was to assess the eligibility using the Y-maze test, involving: latency of the first arm visited, the number of arms visited, and the time spent into the arms, the number of returns of the experimental animals in the same arm, the number of alternations, percentage of spontaneous alternation. In this work, manifestations of the natural behavior of the animals tested was expressed by their choice of goal arm alternation. Statistical data processing reveals that: the administration of IDZ, as well as of EFR was accompanied by a tendency to enter a less recently visited arm and reduced the total number of arms visited, statistically significant (p[0.05) compared to control group. In this experiment, the use of these two imidazoline receptor antagonists did not considerably influence the reference memory, when pursuing the latency of the first arm visited, compared to the group treated with distilled water. The effects of IDZ and EFR on the percentage of time spent in the arms were sorted in descending order in this behavioral experimental model (IDZ]Control]EFR). The results demonstrate that the treatment with imidazoline agents optimizes the cognitive function of the animals, improving their learning ability, in the rat Y-maze Test. Regular exercise can reduce depression-, anxiety-, and impaired cognitive-like behaviors, and in conclusion these substances would be a useful pharmacological agents for the treatment of cognitive dysfunction.
Highlights
Investigating the effects of idazoxan and efaroxan imidazoline receptor antagonists on cognitive functions with the rat Y-maze test; an internationally recognized experimental pattern of behavior, is to be used in order to evaluate the effects of test substances on the simple spatial memory of the laboratory animals
The use of these two imidazoline receptor antagonists did not considerably influence the reference memory, when pursuing the latency of the first arm visited, compared to the group treated with distilled water
These results suggest that agmatine and the imidazoline receptor system may be implicated in overcoming alcohol withdrawal symptoms such as anxiety
Summary
GABRIELA RUSU-ZOTA1, DANIEL VASILE TIMOFTE2*, ELENA ALBU1, PETRONELA NECHITA3, VICTORITA SORODOC4. To reconcile distribution and pharmacological data, imidazoline (I) receptors have been involved in the regulation of the blood pressure, anti-inflammation, hyperglycemia, antitumor activities and cognitive function Studying their distribution in the central nervous system plays an important role in the formation of long-term memories and establish a neurological basis for the complex pharmacological effects of centrally acting idazoxan and efaroxan. In most cases, studying the imidazoline agents on motor behavior and spatial memory justifies the present experimental researches, trying to elucidate the mechanisms that are not fully understood, of both imidazoline receptor antagonists idazoxan and efaroxan, and to assess their involvement in mediating stress and cognitive functions in laboratory animals [14]. 4,5-dihydro-1H-imidazol] regarding some aspects of memory in rodents
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