Abstract
Bladder surface mucin (BSM) is a heterogeneous substance composed of proteoglycans, glycosaminoglycans, and glycoproteins. There is strong evidence that this layer protects the underlying urothelium from bacterial invasion, tumor implantation, and noxious agents in the urine. Alterations of BSM are associated with urothelial permeability changes and enhancement of bacterial adhesion. This protective film is commonly disrupted during endoscopic and open urologic procedures. We hypothesize that the production of BSM is enhanced as a consequence of bladder trauma, thus facilitating bladder repair. In this study, we analyze changes in a high-molecular weight urinary glycoprotein component of bladder surface mucin, glycoprotein-51 (GP-51), before and after hydrodistention.
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