Abstract
We investigated the effects of the H2S and CO gasomediators on Ca2+-dependent potassium channels and an anion exchanger, which participate in the induction of the hyperpolarization response of the erythrocyte membrane and play an important role in regulation of the volume and deformability of erythrocytes. We showed that in the presence of H2S and CO donors, the amplitude of the redox-stimulated membrane hyperpolarization decreased significantly due to a decrease in the activity of Ca2+-dependent potassium channels. It was found that H2S and CO eliminate the compression of erythrocytes observed during activation of Ca2+-dependent potassium channels or inhibition of the anion exchanger. It was shown that the H2S donor significantly increases the erythrocyte deformability.
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