Abstract
Detrusor smooth muscle (DSM) instability is a common symptom of over active bladder (OAB) which effects quality of millions of lives. The enhanced spontaneous contraction due to generation of more frequent spontaneous action potentials (AP) is the fundamental cause of DSM instability. Ca2+ dependent potassium channels are abundantly distributed in DSM cells and regulate the membrane excitability by modulating AP shape and the resting membrane potential. Quantitative studies of these channels will help to predict the underlying mechanism of electrical signaling in DSM cells. Here, we present a large conductance Ca2+ dependent potassium (BK) channel based upon Hodgkin-Huxley (HH) formalism which is incorporated into a published single DSM cell model to investigate several modulating effects. This simple BK ion channel model is constructed with biophysical details from documented electrophysiological studies. As it reflects several modulating properties found in DSM cell electrophysiology, further investigation can shed light in genesis of OB.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
