Abstract
Pyrimethamine, in oral doses averaging 5–6.2 mg/kg/day for 10–21 days, produced a distinctive pattern of toxicity in healthy beagles. This toxicity resembled that produced by antifolate agents and was characterized by emesis, anorexia, diarrhea (occasionally bloody), and weakness followed by malaise, cachexia, and marked body weight loss. Leukopenia, reticulocytopenia, and intestinal degeneration and atrophy indicated that the target organs were the hematopoietic system and the digestive tract. Administration of folinic acid (0.3 mg/kg/day, im) but not folic acid (7.5 mg/kg/day, po) simultaneously with pyrimethamine protected beagles against the toxicity produced by pyrimethamine.
Published Version
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