Abstract
Aldosterone was administered intramuscularly to four adults and seven children with cystic fibrosis while they were maintained on constant sodium, potassium, and fluid intake. The children were studied also during restricted sodium intake. The sweat glands of the children showed an unexpected ability to respond by significantly retaining sodium and excreting additional potassium. Adult patients did not retain sodium, but the increase in potassium excretion was significant. These responses were independent of sweat output. The renal responses of the children with cystic fibrosis were different from those of the adults but similar to those of normal children. The studies support the hypothesis of an abnormality in both the coil and duct of the sweat glands of patients with cystic fibrosis.
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