CYSTIC FIBROSIS OF THE PANCREAS: CLINICAL STAFF CONFERENCE AT THE NATIONAL INSTITUTES OF HEALTH

Abstract

Clinical Staff Conference1 March 1961CYSTIC FIBROSIS OF THE PANCREAS: CLINICAL STAFF CONFERENCE AT THE NATIONAL INSTITUTES OF HEALTHPAUL A. DI SANT'AGNESE, M.D., WILLIAM O. JONES, M.D., ZACHARIAS DISCHE, M.D.PAUL A. DI SANT'AGNESE, M.D.Search for more papers by this author, WILLIAM O. JONES, M.D.Search for more papers by this author, ZACHARIAS DISCHE, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-3-482 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDr. Paul A. di Sant'Agnese: In recent years there has been an increasing interest in cystic fibrosis of the pancreas. It is now recognized that this generalized, inheritable disease which leads to dysfunction of all exocrine glands, mucus-producing and others, is one of the most common chronic diseases of childhood. In this country at the present time cystic fibrosis accounts for virtually all cases of pancreatic deficiency in the pediatric age group, for the majority of patients with chronic (nontuberculous) pulmonary disease, and presents a unique abnormality of sweat electrolytes, in that their concentration is markedly increased.1Although in the...Bibliographyl. di Sant'AgneseVidaurreta PAAM: Cystic fibrosis of the pancreas. J. A. M. A. 172: 135, 1960. Google Scholar2. di Sant'AgneseAndersen PADH: Cystic fibrosis of the pancreas in young adults. Ann. Intern. Med. 50: 1321, 1959. LinkGoogle Scholar3. BohnKochKochRickRau HEFWR: Die Erwachsenen-Mucoviscidosis als uberaus haufige dominant erbliche Krankheit. Die Medizin. 24: 1139, 1959. Google Scholar4. Koch VE: Die erbliche Erwachsenen-Mucoviscidosis und Ihre Beziehungen zur Ulkuskrankheit. Deutsche Med. Wschr. 84: 1773, 1959. CrossrefMedlineGoogle Scholar5. ShwachmanLeubnerCatzel HHP: Mucoviscidosis. Advance. Pediat. 7: 249, 1955. MedlineGoogle Scholar6. PittmanHoweGoodedi Sant'Agnese FECLPA: Phage groups and antibiotic sensitivity of Staphylococcus aureus associated with cystic fibrosis of the pancreas. Pediatrics 24: 40, 1959. MedlineGoogle Scholar7. Halbertdi Sant'AgneseKotek SPPAFR: Staphylococcal antibodies in cystic fibrosis of the pancreas. Pediatrics 26: 792, 1960. Google Scholar8. di Sant'Agnese PA: Recent observations on pathogenesis of cystic fibrosis of the pancreas. Pediatrics 24: 313, 1959. MedlineGoogle Scholar9. WoodFishmanReemtsmaBarkerdi Sant'Agnese JAAPKHGPA: A comparison of sweat chlorides and intestinal fat absorption in chronic obstructive pulmonary emphysema and fibrocystic disease of the pancreas. New Engl. J. Med. 260: 951, 1959. CrossrefMedlineGoogle Scholar10. Hsia DY: Inborn errors of metabolism. Year Book Publishers, Inc., Chicago, 1959. Google Scholar11. Van MetreCookeGibsonWinkenwerder TERELEWL: Evidence of allergy in patients with cystic fibrosis of the pancreas. J. Allergy 31: 141, 1960. CrossrefMedlineGoogle Scholar12. KulczyckiMuellerShwachman LHH: Respiratory allergy in patients with cystic fibrosis: a study of 266 patients. J. A. M. A. 175: 358, 1961. CrossrefMedlineGoogle Scholar13. di Sant'AgneseDischeDanilczenko PAZA: Physicochemical differences of mucoproteins in duodenal fluid of patients with cystic fibrosis of the pancreas and controls: clinical aspects. Pediatrics 19: 252, 1957. MedlineGoogle Scholar14. Dischedi Sant'AgnesePallaviciniYoulos ZPAJCJ: Composition of mucoid fractions from duodenal fluid of children and of adults. Arch. Biochem. 84: 205, 1959. CrossrefMedlineGoogle Scholar15. Dischedi Sant'AgnesePallaviciniYoulos ZPAJCJ: Composition of mucoprotein fractions from duodenal fluid of patients with cystic fibrosis of the pancreas and from controls. Pediatrics 24: 74, 1959. MedlineGoogle Scholar16. Bauer U: A biochemical study of the mucopolysaccharides present in several body fluids of children suffering from fibrocystic disease of the pancreas and normal controls. Ann. Paediat. 194: 236, 1960. MedlineGoogle Scholar17. GabrielDainZinsserDische OJHHZ: Fractionation of nondialyzable carbohydrate-protein complexes of the male urine. Arch. Biochem. 86: 155, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication December 19, 1960.This is an edited transcription of a combined clinical staff conference at the Clinical Center, Bethesda, Maryland, by the National Institutes of Health, Public Health Service, Department of Health, Education, and Welfare.Requests for reprints should be addressed to Paul A. di Sant'Agnese, M.D., National Institutes of Health, Bethesda 14, Maryland. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIncidence of cystic fibrosis in black children—revisitedCourse of cystic fibrosis in black patientsCystic Fibrosis in Young AdultsThe effects of exogenous aldosterone on sweat electrolytesManagement of patients with cor pulmonale—Acute and chronicThe Pancreas and Systemic DiseasePankreasdiagnostikMalabsorptionTHE ECCRINE SWEAT DEFECT IN CYSTIC FIBROSIS OF THE PANCREAS (MUCOVISCIDOSIS) 1 March 1961Volume 54, Issue 3Page: 482-502KeywordsCystic fibrosisGeneticsMedical servicesPancreasPrevention, policy, and public healthPseudomonas aeruginosaPulmonary diseasesPulmonary fibrosisSaltsSweat Issue Published: 1 March 1961 PDF downloadLoading ...