Abstract
Six normal children and eight normal adults received exogenous aldosterone intramuscularly while being maintained on constant sodium, potassium, and fluid intake. Both groups showed active sweat gland responses, with characteristics in many ways different from responses of the kidney. The effects were independent of dosage and were reversible with spironolactone. Sweat sodium retention during administration of aldosterone was not necessarily dependent upon a decrease in sweat rate. The renal response to exogenous aldosterone in children was quite different from that of adults, and may be related to age.
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