Abstract
Objectives: To evaluate short-term and long-term effects of estrogen replacement therapy (ERT) on lipid profile in surgically menopaused women. Methods: In this cross-sectional study, 120 surgically menopaused women after total hysterectomy and bilateral oophorectomy and 107 natural postmenopausal womenwere enrolled. After surgical menopause, 28 women received 0.625mg conjugated equine estrogen (CEE) and 32 women did not for 3months, 28women received and 32 women were did not for 1 year. Natural postmenopausal women received 0.625 mg conjugated equine estrogen (CEE) and 5 mg medroxyprogesterone acetate (MPA). The effects of hormone therapy on plasma levels of lipids were investigated. Results:During hormone therapy, total cholesterol and LDL cholesterol level decreased significantly for 3 months and 1 year in surgically menopaused women (P 0.05). Triglyceride level decreased in surgically menopaused women had not received ERT but there was no significant statistical difference (P>0.05). Conclusion:The results of our study results suggest that ERT had more beneficial effects on lipid profile in surgically menopaused women.
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