Abstract
ABSTRACTThe objective present study was to determine sialoadenectomy and exogenous EGF administration effects on light microscopic changes in a rat kidney. Adult female Wistar albino rats used. The animals divided into three groups randomly. Group-I: The animals served as control (n:10). Group-II: Sialoadenectomy (n:10), Group-III: Sialoadenectomy+EGF administration (n:10). After 27 days sialoadenectomy, Control and experimental groups rats were killed by pentobarbital and their kidney removed. The tissue samples were examined under light microscope. Light microscopic evaluation indicated that the kidney tubules epithelium and glomerules in control group showed a normal appearance while changes were observed in all experimental groups. However, SX+ exogenous EGF administration group was performing a nearer light microscopic view of to the control group. In this study we indicated that short term exogenous EGF supplementation in sialoadenectomized rats can relativly increase kidney light microscopic improvoment.
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